Tufail, Fatima published the artcileCatalyst-Free, Glycerol-Assisted Facile Approach to Imidazole-Fused Nitrogen-Bridgehead Heterocycles, COA of Formula: C14H11BrN2, the main research area is imidazopyridine imidazopyrimidine imidazopyrazine preparation regioselective green chem; phenacyl bromide aminopyridine aminopyrimidine aminopyrazine coupling glycerol solvent.
A completely regioselective, environmentally benign strategy for the facile synthesis of biol. important imidazole-fused nitrogen-bridgehead heterocycles has been developed using glycerol/water 4:1 as a green promoting media. The methodol. involves the simple coupling of 2-halocarbonyl compounds with 2-aminopyridines, 2-aminopyrimidine, 2-aminopyrazine to obtain a variety of 2-aryl substituted imidazo-pyridines, imidazo-pyrimidines and imidazo-pyrazines containing bridgehead nitrogen. This protocol eliminates the use of toxic catalysts and volatile organic solvents – two key principles in the development of a green chem. process. Other significant highlights include mild reaction conditions, operational simplicity, short reaction times, easy workup and purification process, high yields and potential for scale-up.
ChemistrySelect published new progress about Coupling reaction. 1023-01-4 belongs to class imidazoles-derivatives, name is 2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine, and the molecular formula is C14H11BrN2, COA of Formula: C14H11BrN2.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem