Moustakim, Moses published the artcileDiscovery of an MLLT1/3 YEATS Domain Chemical Probe, SDS of cas: 94084-75-0, the main research area is MLLT1 YEATS domain chem probe; MLLT1; MLLT3; YEATS; chemical probes; epigenetics.
YEATS domain (YD) containing proteins are an emerging class of epigenetic targets in drug discovery. Dysregulation of these modified lysine-binding proteins has been linked to the onset and progression of cancers. We herein report the discovery and characterization of the first small-mol. chem. probe, SGC-iMLLT, for the YD of MLLT1 (ENL/YEATS1) and MLLT3 (AF9/YEATS3). SGC-iMLLT is a potent and selective inhibitor of MLLT1/3-histone interactions. Excellent selectivity over other human YD proteins (YEATS2/4) and bromodomains was observed Furthermore, our probe displays cellular target engagement of MLLT1 and MLLT3. The first small-mol. X-ray co-crystal structures with the MLLT1 YD are also reported. This first-in-class probe mol. can be used to understand MLLT1/3-associated biol. and the therapeutic potential of small-mol. YD inhibitors.
Angewandte Chemie, International Edition published new progress about Antitumor agents. 94084-75-0 belongs to class imidazoles-derivatives, name is 4-((1H-Imidazol-1-yl)methyl)benzoic acid, and the molecular formula is C11H10N2O2, SDS of cas: 94084-75-0.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem