Kiselyov, Alexander S. published the artcile2-((1H-Azol-1-yl)methyl)-N-arylbenzamides: Novel dual inhibitors of VEGFR-1/2 kinases, COA of Formula: C9H10N2O2, the main research area is azolyl arylbenzamide preparation VEGFR kinase inhibitor SAR.
Novel potent derivatives of (azol-1-yl)methyl-N-arylbenzamides with improved solubility (>3 mM) are described as ATP-competitive inhibitors of vascular endothelial growth factor receptor 2 (VEGFR-2). Many compounds display VEGFR-2 inhibitory activity reaching IC50 < 100 nM in the enzymic assay. The compounds also inhibit the related tyrosine kinase, VEGFR-1, with similar potencies. Several compounds containing bulky lipophilic substituents at the benzamide pharmacophore yielded 10- to 17-fold selectivity for the VEGFR-2 vs. VEGFR-1 kinase. Bioorganic & Medicinal Chemistry Letters published new progress about Molecular modeling. 72721-02-9 belongs to class imidazoles-derivatives, name is 5,6-Dimethoxy-1H-benzo[d]imidazole, and the molecular formula is C9H10N2O2, COA of Formula: C9H10N2O2.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem