De Clercq, Erik’s team published research in Life Sciences in 1975 | CAS: 30086-17-0

Life Sciences published new progress about Antiviral agents. 30086-17-0 belongs to class imidazoles-derivatives, name is 5-Fluoro-1H-imidazole, and the molecular formula is C3H3FN2, SDS of cas: 30086-17-0.

De Clercq, Erik published the artcileFluoroimidazoles as antiviral agents and inhibitors of polynucleotide biosynthesis, SDS of cas: 30086-17-0, the main research area is fluoroimidazole virus nucleotide.

4-Fluoroimidazole (4-FI) [30086-17-0], 4-fluoroimidazole-5-carboxylic acid (4-FIC) [42309-90-0], 4-fluoroimidazole-5-carboxamide (4-FICA ) [33300-35-5], and 5-fluoro-1-β-D-ribofuranosylimidazole-4-carboxamide (5-FICAR) [56766-95-1] were studied for their inhibitory effects on viral cytopathogenicity in 10 assay systems encompassing nearly all major virus groups. Ribavirin (1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide) [36791-04-5], 5-AICAR (5-amino-1-β-D-ribofuranosylimidazole-4-carboxamide) [2627-69-2], and poly (I)-poly (C) [24939-03-5] were included as reference materials. Although the antiviral activities of ribavirin and the fluoroimidazoles varied considerably from 1 system to another, the relative order of activity remained constant: ribavirin > 5-FICAR > 5-AICAR > 4-FICA. 4-FIC and 4-FI were inactive. Poly (I)-poly (C) showed a spectrum of antiviral activity that differed totally from that of 5-FICAR and the other compounds Unlike 5-AICAR, both 5-FICAR and ribavirin inhibited cellular DNA and RNA synthesis at concentrations which coincided quite well with those inhibiting viral cytopathogenicity. Hence, 5-FICAR and ribavirin may owe their broad-spectrum antiviral activity to inhibition of nucleic acid synthesis in the infected cell.

Life Sciences published new progress about Antiviral agents. 30086-17-0 belongs to class imidazoles-derivatives, name is 5-Fluoro-1H-imidazole, and the molecular formula is C3H3FN2, SDS of cas: 30086-17-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem