Raczynska, E. D. published the artcileApplication of semiempirical method (AM1) to the study of tautomeric equilibria in the gas phase for simple compounds containing the amidine group: 4(5)-substituted imidazoles, HPLC of Formula: 30086-17-0, the main research area is MO gas phase tautomeric equilibrium imidazole; protonation amidine imidazole derivative; acid base equilibrium amidine imidazole derivative.
Semiempirical method (AM1) has been used to predict the tautomeric equilibrium constants (pKT) in the gas phase for 4(5)-substituted imidazoles. The pKT values have been calculated on the basis of heats of formation of individual tautomers. In calculations it has been assumed that the TΔS term has the same value for both tautomers. For comparison, the pKT values have also been estimated on the basis of the calculated (by AM1) proton affinities of N-methyl-4- and 5-substituted imidazoles. Both estimations give almost the same pKT values. Obtained results are compared with those found in solution Comparison shows that the gas-phase substituent effects do not reproduce well those in solution To find an explanation of this observation, the influence of rotational isomerism of substituent on the tautomeric equilibrium constant has been studied. Proton affinities and deprotonation enthalpies of 4- and 5-substituted imidazoles have also been calculated For unsubstituted imidazole, 4(5)-methyl-imidazole and their N-Me derivatives they are compared with those exptl. obtained. Errors are considerably smaller than the average errors of AM1 method for nitrogen acids and bases.
Analytica Chimica Acta published new progress about Acid-base equilibrium. 30086-17-0 belongs to class imidazoles-derivatives, name is 5-Fluoro-1H-imidazole, and the molecular formula is C3H3FN2, HPLC of Formula: 30086-17-0.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem