Gianotti, Massimo published the artcileNovel imidazobenzazepine derivatives as dual H1/5-HT2A antagonists for the treatment of sleep disorders, SDS of cas: 30086-17-0, the main research area is imidazo benzazepine derivative preparation dual H1 5HT2A antagonist structure; sleep disorder imidazo benzazepine derivative.
A novel imidazobenzazepine template (5a) with potent dual H1/5-HT2A antagonist activity was identified. Application of a zwitterionic approach to this poorly selective and poorly developable starting point successfully delivered a class of high quality leads, 3-[4-(3-R1-2-R-5H-imidazo[1,2-b][2]benzazepin-11-yl)-1-piperazinyl]-2,2-dimethylpropanoic acids (e.g., 9, 19, 20, and 21), characterized by potent and balanced H1/5-HT2A receptor antagonist activities and good developability profiles.
Bioorganic & Medicinal Chemistry Letters published new progress about 5-HT2A antagonists. 30086-17-0 belongs to class imidazoles-derivatives, name is 5-Fluoro-1H-imidazole, and the molecular formula is C3H3FN2, SDS of cas: 30086-17-0.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem