Chattopadhyay, Gautam published the artcileA domino type one-flask synthesis of 1-substituted-5-aminoimidazole-4-carboxamides and ring transformation to pyrazine under microwave through suitable aminoimidazoliumcarboxamide, COA of Formula: C5H8N4O, the main research area is aminoimidazolecarboxamide preparation ring expansion; imidazolecarboxamide amino preparation ring expansion; pyrazinone preparation; oximinocyanoacetamide amine reductive heterocyclization.
Reductive heterocyclization of H2NCOC(:NOH)CN in the presence of HC(OEt)3 and appropriate amines affords 1-substituted 5-aminoimidazole-4-carboxamides. 4-Amino-5-carboxamido-3-diphenylmethyl-1-phenacylimidazolium bromide, generated in situ from 5-amino-1-(diphenylmethyl)imidazole-4-carboxamide, furnishes a ring-expanded pyrazine, 3-{amino[(diphenylmethyl)amino]methylene}-6-phenyl-2-pyrazinone, with methanolic alkali under microwave irradiation in excellent yield.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about Microwave irradiation. 21343-04-4 belongs to class imidazoles-derivatives, name is 5-Amino-1-methyl-1H-imidazole-4-carboxamide, and the molecular formula is C5H8N4O, COA of Formula: C5H8N4O.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem