Kulkarni, Surendra published the artcileNucleophilic displacements of imidazoles. II. Displacements of halogen by S-nucleophiles and displacements of mesyl groups activated by nitro; oxidation of imidazolethiols, Synthetic Route of 18874-52-7, the main research area is sulfonylimidazole; nitrothioimidazole; thionitroimidazole; substitution nucleophile halonitroimidazole thiophenol kinetics; mesylnitroimidazole nucleophile substitution; imidazolethiol preparation oxide.
RC6H4SH (R = H, p-Me) react with halonitroimidazoles I and II (R1, R2 = H, Me; R3 = Br, iodo) to give I and II (R3 = SC6H4R). The bromo compounds are slightly more reactive than the iodo analogs. Substituents at C-5 are more readily displaced than those at C-4. I and II (R3 = SO2Me) undergo nucleophilic substitution reactions with a variety of nucleophiles (e.g., PhSH, MeO-, piperidine). The imidazolethiol products are readily oxidized to the sulfones.
Australian Journal of Chemistry published new progress about Nucleophilic substitution reaction. 18874-52-7 belongs to class imidazoles-derivatives, name is 5-Bromo-2-methyl-4-nitroimidazole, and the molecular formula is C4H4BrN3O2, Synthetic Route of 18874-52-7.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem