Hall, Janet A. published the artcileThe induction of errors during in vitro DNA synthesis following chloroacetaldehyde-treatment of poly(dA-dT) and poly(dC-dG) templates, Application In Synthesis of 274-78-2, the main research area is chloroacetaldehyde DNA polymer reaction; polymerase DNA chloroacetaldehyde; ethenoadenine chloroacetaldehyde DNA; ethenocytosine chloroacetaldehyde DNA.
Chloroacetaldehyde [107-20-0], a rearranged metabolic product of the human carcinogen vinyl chloride, reacts with the DNA-like polymers poly(dA-dT) [26966-61-0] and poly(dC-dG) [62081-33-8] to form etheno-adducts of the adenine and cytosine bases. These treated polymers, when used as templates for Escherichia coli DNA polymerase I [9012-90-2] in an in vitro assay, show a decreased ability to direct DNA synthesis. At the same time, increased relative levels of noncomplementary nucleotides are incorporated. With the poly(dA-dT) templates, 1 dGMP residue is incorporated for every ∼60 ethenoadenine [13875-63-3] residues present, whereas no increased misincorporation of dCMP was detected. With the poly(dC-dG) templates, 1 misincorporation of dAMP or dTMP occurred in the presence of ∼30 and 80 ethenocytosine [274-78-2] residues, resp. A nearest neighbor anal. shows that with the modified poly(dC-dG) templates, the majority of the errors were incorporated opposite cytosine (or modified cytosine) bases.
Carcinogenesis published new progress about DNA Role: BIOL (Biological Study). 274-78-2 belongs to class imidazoles-derivatives, name is Imidazo[1,2-c]pyrimidine, and the molecular formula is C6H5N3, Application In Synthesis of 274-78-2.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem