Alhede, Boerge published the artcileA simple and efficient synthesis of 9-substituted guanines. Cyclodesulfurization of 1-substituted 5-[(thiocarbamoyl)amino]imidazole-4-carboxamides under aqueous basic conditions, Related Products of imidazoles-derivatives, the main research area is guanine substituted; thiocarbamoylaminoimidazolecarboxamide cyclodesulfurization metal salt catalyzed; imidazolecarboxamide thiocarbamoyl cyclodesulfurization alk; nucleoside acyclo; desulfurization cyclo thiocarbamoylaminoimidazolecarboxmide; acyclonucleoside.
5-Aminoimidazole-4-carboxamide (I; R = R1 = H) is 1-alkylated by an improved method. The resulting alkylimidazolecarboxamides, e.g. I (R = Me, Et, Pr, PhCH2, HOCH2CH2O, R1 = H), are converted to the corresponding thiocarbamoylcarboxamides, e.g. I (R = same, R1 = CSNH2). These compounds are ring closed under alk. conditions to 9-substituted guanines II (R = same) in very high yields by treatment with heavy-metal salts in aqueous NaOH, or, in lower yields, by S-oxidation with H2O2 or NaBO3 in aqueous NaOH.
Journal of Organic Chemistry published new progress about Cyclocondensation reaction catalysts. 21343-04-4 belongs to class imidazoles-derivatives, name is 5-Amino-1-methyl-1H-imidazole-4-carboxamide, and the molecular formula is C5H8N4O, Related Products of imidazoles-derivatives.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem