On September 3, 2021, Zeng, Juan; Zhang, Heying; Tan, Yonggang; Wang, Zhe; Li, Yunwei; Yang, Xianghong published an article.Synthetic Route of 443-72-1 The title of the article was m6A demethylase FTO suppresses pancreatic cancer tumorigenesis by demethylating PJA2 and inhibiting Wnt signaling. And the article contained the following:
Pancreatic cancer is the deadliest malignancy of the digestive system and is the seventh most common cause of cancer-related deaths worldwide. The incidence and mortality of pancreatic cancer continue to increase, and its 5-yr survival rate remains the lowest among all cancers. N6-methyladenine (m6A) is the most abundant reversible RNA modification in various eukaryotic messenger and long noncoding RNAs and plays crucial roles in the occurrence and development of cancers. However, the role of m6A in pancreatic cancer remains unclear. The present study aimed to explore the role of m6A and its regulators in pancreatic cancer and assess its underlying mol. mechanism associated with pancreatic cancer cell proliferation, invasion, and metastasis. Reduced expression of the m6A demethylase, fat mass and obesity-associated protein (FTO), was responsible for the high levels of m6A RNA modification in pancreatic cancer. Moreover, FTO demethylated the m6A modification of praja ring finger ubiquitin ligase 2 (PJA2), thereby reducing its mRNA decay, suppressing Wnt signaling, and ultimately restraining the proliferation, invasion, and metastasis of pancreatic cancer cells. Altogether, this study describes new, potential mol. therapeutic targets for pancreatic cancer that could pave the way to improve patient outcome. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Synthetic Route of 443-72-1
The Article related to m6a demethylase fto pancreatic cancer pja2 tumorigenesis wnt signaling, n6-methyladenine, pja2, wnt signaling, m6a demethylase fto, pancreatic cancer, Placeholder for records without volume info and other aspects.Synthetic Route of 443-72-1
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Imidazole | C3H4N2 – PubChem