Sheng, Yalan; Pan, Bo; Wei, Fan; Wang, Yuanyuan; Gao, Shan published an article in 2021, the title of the article was Case study of the response of N6-methyladenine DNA modification to environmental stressors in the unicellular eukaryote Tetrahymena thermophila.Application In Synthesis of N-Methyl-7H-purin-6-amine And the article contains the following content:
Study on the dynamic changes of 6mA under starvation in the unicellular model organism Tetrahymena thermophila. Single-mol., real-time (SMRT) sequencing reveals that DNA 6mA levels in starved cells are significantly reduced, especially sym. 6mA, compared to those in vegetatively growing cells. Despite a global 6mA reduction, the fraction of asym. 6mA with a high methylation level was increased, which might be the driving force for stronger nucleosome positioning in starved cells. Starvation affects expression of many metabolism-related genes, the expression level change of which is associated with the amount of 6mA change, thereby linking 6mA with global transcription and starvation adaptation. These results demonstrated that a regulated 6mA response to environmental cues is evolutionarily conserved in eukaryotes. Increasing evidence indicated that 6mA could respond to environmental stressors in multicellular eukaryotes. As 6mA distribution and function differ significantly in multicellular and unicellular organisms, whether and how 6mA in unicellular eukaryotes responds to environmental stress remains elusive. In the present work, we characterized the dynamic changes of 6mA under starvation in the unicellular model organism Tetrahymena thermophila. Our results provide insights into how Tetrahymena fine-tunes its 6mA level and composition upon starvation, suggesting that a regulated 6mA response to environmental cues is evolutionarily conserved in eukaryotes. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Application In Synthesis of N-Methyl-7H-purin-6-amine
The Article related to tetrahymena environmental stress n6 methyladenine dna modification, 6ma, tetrahymena thermophila, starvation, unicellular eukaryote, Placeholder for records without volume info and other aspects.Application In Synthesis of N-Methyl-7H-purin-6-amine
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem