Qu, Shanqiang; Chen, Zhixin; Liu, Bin; Liu, Jin; Wang, Huafu published an article in 2021, the title of the article was N6-methyladenine-related genes affect biological behavior and the prognosis of glioma.Application In Synthesis of N-Methyl-7H-purin-6-amine And the article contains the following content:
Although aberrant expression of N6-methyladenine (m6A) methylation-related genes contribute to tumorigenesis in many solid tumors, the prognostic value of the m6A-related genes and their correlation with clinicopathol. features in gliomas need advanced study. Nine m6A-related genes were identified as independent prognostic factors, which were mostly enriched in RNA splicing, regulation of immune response and vesicle-mediated transport. We constructed risk score of each patient, which was highly associated with clinicopathol. features. Kaplan-Meier curve showed that the prognosis of patients with high-risk scores was significantly worse than that with low-risk scores (HR = 4.30, 95% CI = 3.16-5.85, p < 0.0001). A nomogram was constructed based on the nine m6A-related genes signature and clinicopathol. features with well-fitted calibration curves (c-index = 0.82), showing high specificity and sensitivity (area under the curve for 1-, 3-, and 5-years survival probability = 0.874, 0.918, and 0.934). A nine m6A-related genes signature was identified in gliomas. The m6A-related risk score is a novel prognostic factor for patients with glioma, and is associated with clinicopathol. features. Moreover, the nomogram based on the nine m6A-related genes signature and clinicopathol. features had good efficacy in predicting the survival probability. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Application In Synthesis of N-Methyl-7H-purin-6-amine
The Article related to glioma n6 methyladenine prognosis, neoplasms, nomograms, prognosis, Placeholder for records without volume info and other aspects.Application In Synthesis of N-Methyl-7H-purin-6-amine
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