Panzica, Raymond P. published the artcileAnalogs of AICA- and iso-AICA ribosides and their methylated base counterparts, Application In Synthesis of 21343-04-4, the main research area is imidazole thiocarboxamide selenocarboxamide riboside preparation kinetics; AICA riboside analog preparation reaction kinetics.
A mild, convenient and efficient synthesis has been developed for imidazole-4-thiocarboxamide and imidazole-5-thiocarboxamide ribosides and the analogous selenocarboxamides. This methodol., i.e., DMF saturated with H2S or H2Se, also converts the corresponding N-methylated bases to the corresponding amides. The imidazole-4(5)-selenocarboxamides were shown to be sensitive to base (pH 11) and were easily converted back to their cyano precursors. The kinetics of these reactions were determined and they indicate that the C5 amides were more reactive than their C4 analogs.
Nucleosides & Nucleotides published new progress about Reaction kinetics. 21343-04-4 belongs to class imidazoles-derivatives, name is 5-Amino-1-methyl-1H-imidazole-4-carboxamide, and the molecular formula is C5H8N4O, Application In Synthesis of 21343-04-4.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem