On January 5, 2011, Joseph, Kara M.; Larraza-Sanchez, Isabel published an article.Application In Synthesis of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole The title of the article was Synthesis of benzyl bromides with hexabromoacetone: an alternative path to drug intermediates. And the article contained the following:
A series of benzyl bromides were efficiently prepared from the corresponding alcs. with Br3CCOCBr3/PPh3 at low temperatures and under neutral conditions. The present protocol was applied to the heterocyclic analogs and to the successful synthesis of the precursor of the antiulcer drug omeprazole, thus furnishing an alternative, mild method for the preparation of this type of drugs’ intermediates. A significant steric factor was observed throughout both series supporting a SN2 mechanism. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Application In Synthesis of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole
The Article related to benzyl alc bromination hexabromoacetone, bromide benzyl preparation drug precursor, hexabromoacetone triphenylphosphine bromination agent, General Organic Chemistry: Synthetic Methods and other aspects.Application In Synthesis of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem