On December 31, 2022, Guan, Qian; Lin, Huiran; Miao, Lei; Guo, Huiqin; Chen, Yongping; Zhuo, Zhenjian; He, Jing published an article.Name: N-Methyl-7H-purin-6-amine The title of the article was Functions, mechanisms, and therapeutic implications of METTL14 in human cancer. And the article contained the following:
A review. RNA modification plays a crucial role in many biol. functions, and its abnormal regulation is associated with the progression of cancer. Among them, N6-methyladenine (m6A) is the most abundant RNA modification. Methyltransferase-like 14 (METTL14) is the central component of the m6A methylated transferase complex, which is involved in the dynamic reversible process of m6A modification. METTL14 acts as both an oncogene and tumor suppressor gene to regulate the occurrence and development of various cancers. The abnormal m6A level induced by METTL14 is related to tumorigenesis, proliferation, metastasis, and invasion. To date, the mol. mechanism of METTL14 in various malignant tumors has not been fully studied. In this paper, we systematically summarize the latest research progress on METTL14 as a new biomarker for cancer diagnosis and its biol. function in human tumors and discuss its potential clin. application. This study aims to provide new ideas for targeted therapy and improved prognoses in cancer. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Name: N-Methyl-7H-purin-6-amine
The Article related to review cancer mettl14 rna modification biomarkers, cancer, drug discovery, mettl14, rna modification, m6a, Placeholder for records without volume info and other aspects.Name: N-Methyl-7H-purin-6-amine
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem