On May 11, 2018, Gu, Zhen; Yu, Jicheng published a patent.Name: 2-Nitro-1H-benzo[d]imidazole The title of the patent was Patch loaded with dual-sensitive vesicles for enhanced glucose-responsive insulin delivery. And the patent contained the following:
A composition comprising an amphiphilic polymeric material that is both hydrogen peroxide- and hypoxia-sensitive is described. The composition can further include a glucose-oxidizing enzyme and insulin, a bioactive derivative thereof, and/or another therapeutic agent (e.g., another diabetes treatment agent). The polymeric material can form vesicles that comprise single or multiple layers of the polymeric material that enclose the glucose-oxidizing enzyme and the insulin, bioactive derivative and/or other therapeutic agent. The vesicles can be loaded into microneedles to, for example, prepare microneedle arrays for skin patches. Methods of delivering insulin to a subject using the compositions, vesicles, microneedles, and/or microneedle array skin patches are also described. The experimental process involved the reaction of 2-Nitro-1H-benzo[d]imidazole(cas: 5709-67-1).Name: 2-Nitro-1H-benzo[d]imidazole
The Article related to patch dual sensitive vesicle insulin delivery polymer preparation, Pharmaceuticals: Formulation and Compounding and other aspects.Name: 2-Nitro-1H-benzo[d]imidazole
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem