Blanazs, Alexander; Bristow, Tony W. T.; Coombes, Steven R.; Corry, Tom; Nunn, Mike; Ray, Andrew D. published an article in 2017, the title of the article was Coupling and optimisation of online nuclear magnetic resonance spectroscopy and mass spectrometry for process monitoring to cover the broad range of process concentration.Related Products of 73590-85-9 And the article contains the following content:
Real time online monitoring of chem. processes can be carried out by a number of anal. techniques, including optical and vibrational spectroscopies, NMR (NMR) spectroscopy and mass spectrometry (MS). As each technique has unique advantages and challenges, combinations are an attractive option. The combination of a 500-MHz 1H NMR and a small footprint mass spectrometer to monitor a batch reaction at process concentration was investigated. The mass spectrometer was coupled into the flow path of an online reaction monitoring NMR. Reaction mixture was pumped from a 100-mL vessel to an NMR flow tube before returning to the vessel. Small aliquots were diverted into a sampling make-up flow using an active flow splitter and passed to the mass spectrometer. Advantages of the combination were observed 1H NMR was ideal for quantitation of high level components, whereas MS showed a greater capability for detecting those at low level. In preliminary experiments MS produced a limited linear relationship with concentration (0.02% to 2% relative concentration, 0.01 mg/mL-1.25 mg/mL), because of signal saturation at the higher concentrations NMR was unable to detect components below 0.1% relative to concentration maximum Optimization of sample transfer to the MS extended the linearity to 10% relative to the concentration maximum Therefore, the combination of online NMR and MS allows both qual. and quant. anal. of reaction components over the full process range. The application of the combination was demonstrated by monitoring a batch chem. reaction and this is described. Copyright æ¼?2016 John Wiley & Sons, Ltd. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Related Products of 73590-85-9
The Article related to nmr spectroscopy mass spectrometry online analysis, ms, nmr, online, process monitoring, Organic Analytical Chemistry: Determinations and other aspects.Related Products of 73590-85-9
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem