Bamborough, Paul’s team published research in Bioorganic & Medicinal Chemistry Letters in 2006-12-15 | CAS: 72721-02-9

Bioorganic & Medicinal Chemistry Letters published new progress about Epidermal growth factor receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 72721-02-9 belongs to class imidazoles-derivatives, name is 5,6-Dimethoxy-1H-benzo[d]imidazole, and the molecular formula is C9H10N2O2, Safety of 5,6-Dimethoxy-1H-benzo[d]imidazole.

Bamborough, Paul published the artcile5-(1H-Benzimidazol-1-yl)-3-alkoxy-2-thiophenecarbonitriles as potent, selective, inhibitors of IKK-ε kinase, Safety of 5,6-Dimethoxy-1H-benzo[d]imidazole, the main research area is IKK kinase inhibitor benzimidazolyl thiophenecarbonitrile preparation SAR.

The identification and hit-to-lead exploration of a novel, potent and selective series of substituted benzimidazole-thiophene carbonitrile inhibitors of IKK-ε kinase is described. Compound 12e (I) was identified with an IKK-ε enzyme potency of pIC50 7.4, and has a highly encouraging wider selectivity profile, including selectivity within the IKK kinase family.

Bioorganic & Medicinal Chemistry Letters published new progress about Epidermal growth factor receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 72721-02-9 belongs to class imidazoles-derivatives, name is 5,6-Dimethoxy-1H-benzo[d]imidazole, and the molecular formula is C9H10N2O2, Safety of 5,6-Dimethoxy-1H-benzo[d]imidazole.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem