On March 4, 2021, Zhu, Pengpeng; He, Fang; Hou, Yixuan; Tu, Gang; Li, Qiao; Jin, Ting; Zeng, Huan; Qin, Yilu; Wan, Xueying; Qiao, Yina; Qiu, Yuxiang; Teng, Yong; Liu, Manran published an article.Category: imidazoles-derivatives The title of the article was A novel hypoxic long noncoding RNA KB-1980E6.3 maintains breast cancer stem cell stemness via interacting with IGF2BP1 to facilitate c-Myc mRNA stability. And the article contained the following:
Abstract: The hostile hypoxic microenvironment takes primary responsibility for the rapid expansion of breast cancer tumors. However, the underlying mechanism is not fully understood. Here, using RNA sequencing (RNA-seq) anal., we identified a hypoxia-induced long noncoding RNA (lncRNA) KB-1980E6.3, which is aberrantly upregulated in clin. breast cancer tissues and closely correlated with poor prognosis of breast cancer patients. The enhanced lncRNA KB-1980E6.3 facilitates breast cancer stem cells (BCSCs) self-renewal and tumorigenesis under hypoxic microenvironment both in vitro and in vivo. Mechanistically, lncRNA KB-1980E6.3 recruited insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) to form a lncRNA KB-1980E6.3/IGF2BP1/c-Myc signaling axis that retained the stability of c-Myc mRNA through increasing binding of IGF2BP1 with m6A-modified c-Myc coding region instability determinant (CRD) mRNA. In conclusion, we confirm that lncRNA KB-1980E6.3 maintains the stemness of BCSCs through lncRNA KB-1980E6.3/IGF2BP1/c-Myc axis and suggest that disrupting this axis might provide a new therapeutic target for refractory hypoxic tumors. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Category: imidazoles-derivatives
The Article related to hypoxia lncrnkb1980e63 breast cancer stem cell igf2bp1 cmyc transcription, Biochemical Genetics: Genomic Processes and other aspects.Category: imidazoles-derivatives
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Imidazole | C3H4N2 – PubChem