Wan, Liqi; Lam, Sik Lok; Lee, Hung Kay; Guo, Pei published an article in 2021, the title of the article was Effects of adenine methylation on the structure and thermodynamic stability of a DNA minidumbbell.Recommanded Product: 443-72-1 And the article contains the following content:
DNA methylation is a prevalent regulatory modification in prokaryotes and eukaryotes. N1-methyladenine (m1A) and N6-methyladenine (m6A) have been found to be capable of altering DNA structures via disturbing Watson-Crick base pairing. However, little has been known about their influences on non-B DNA structures, which are associated with genetic instabilities. In this work, we investigated the effects of m1A and m6A on both the structure and thermodn. stability of a newly reported DNA minidumbbell formed by two TTTA tetranucleotide repeats. As revealed by the results of NMR spectroscopic studies, both m1A and m6A favored the formation of a T·m1A and T·m6A Hoogsteen base pair, resp. More intriguingly, the m1A and m6A modifications brought about stabilization and destabilization effects on the DNA minidumbbell, resp. This work provides new biophys. insights into the effects of adenine methylation on the structure and thermodn. stability of DNA. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Recommanded Product: 443-72-1
The Article related to adenine methylation dna minidumbbell thermodn stability, dna methylation, dna minidumbbell, n1-methyladenine, n6-methyladenine, nuclear magnetic resonance spectroscopy, Biochemical Methods: Biological and other aspects.Recommanded Product: 443-72-1
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