Sutton, W. B.; Gordee, R. S.; Wick, W. E.; Stanfield, La Veda published an article in 1966, the title of the article was In vitro and in vivo laboratory studies on the antituberculous activity of capreomycin.Product Details of 5709-67-1 And the article contains the following content:
The in vitro and in vivo spectrum of the activity of capreomycin (I) was exclusively antimycobacterial. No synergistic effect was found in vitro; however, I in combination with p-amino-salicylic acid (PAS) in vivo was more effective than the use of these agents alone. The emergence of resistance of Mycobacterium tuberculosis H37Rv, Mycobacterium ATCC 607 and M. avium ATCC 7992 to I in vitro was delayed. Induced I-, streptomycin (II)-, isoniazid-, and viomycin- resistant strains of M. tuberculosis H37Rv did not demonstrate cross-resistance with each other or PAS. II and I cross-resistance was not observed with other mycobacteria. Orally administered, I exhibited a low order of activity. Subcutaneous treatment with I was effective against M. tuberculosis strain H37Rv and M. kanasii in exptl. mouse tuberculosis. The antibiotic had significant activity against exptl. bovine tuberculosis in mice. I was effective against II-resistant M. tuberculosis H37Rv in vivo. Resistant organisms were not isolated following prolonged I treatment. The experimental process involved the reaction of 2-Nitro-1H-benzo[d]imidazole(cas: 5709-67-1).Product Details of 5709-67-1
The Article related to animals, anti-bacterial agents: pharmacology, antitubercular agents: pharmacology, bacteria: drug effects, in vitro techniques, infections: drug therapy, mice, mycobacterium: drug effects, mycobacterium tuberculosis: drug effects and other aspects.Product Details of 5709-67-1
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Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem