Shan, Li; Lu, Ye; Song, Yihua; Zhu, Xiaoli; Xiang, Cheng-Cheng; Zuo, Er-Dong; Cheng, Xu published an article in 2022, the title of the article was Identification of nine M6A-related long noncoding RNAs as prognostic signatures associated with oxidative stress in oral cancer based on data from the cancer genome atlas.Synthetic Route of 443-72-1 And the article contains the following content:
Objective. Although the expression of long noncoding RNAs (lncRNAs) and N6-methyladenosine (M6A) is correlated with different tumors, it remains unclear how M6A-related lncRNA functioning affects the initiation and progression of oral squamous cell carcinoma (OSCC). Materials and Methods. Gene expression and clin. data were retrieved from The Cancer Genome Atlas. The prognostic value of M6A-related lncRNAs was determined using univariate Cox regression analyses. Gene set enrichment anal. of OSCC patient clusters revealed the pathways that elucidate the mechanism. Furthermore, a risk-based model was established. The difference in the overall survival (OS) between groups, including low-/high-risk groups, was determined by Kaplan-Meier anal. Relationships among immune cells, clusters, clinicopathol. characteristics, and risk scores were explored. Results. Among 1,080 M6A-related lncRNAs, 36 were prognosis-related. Patients with OSCC were divided into two clusters. T stage and the pathol. grade were noticeably lower in cluster 2 than in cluster 1. Epithelial-mesenchymal transition showed greater enrichment in cluster 1. Nine hub M6A-related lncRNAs were identified for the model of risk score for predicting OSCC prognosis. The OS was longer in patients with a low-risk score than in patients with a high-risk score. The risk score was an independent prognostic factor of OSCC and was associated with the infiltration of different immune cells. T stages and the American Joint Committee on Cancer (AJCC) stages were more advanced in the high-risk score group than in the low-risk score group. Finally, expression correlation anal. showed that the risk score is associated with the expression of oxidative stress markers. Conclusion. M6A-related lncRNAs play an important role in OSCC progression. Immune cell infiltration was related to the risk score model in OSCC and could accurately predict OSCC prognosis. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Synthetic Route of 443-72-1
The Article related to adenine: analogs & derivatives, biomarkers, tumor: genetics, biomarkers, tumor: metabolism, carcinoma, squamous cell: diagnosis, carcinoma, squamous cell: genetics, carcinoma, squamous cell: pathology, gene expression regulation, neoplastic, head and neck neoplasms: diagnosis, head and neck neoplasms: genetics, humans and other aspects.Synthetic Route of 443-72-1
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