On March 31, 2022, Lin, Qu; Chen, Jun-wei; Yin, Hao; Li, Ming-an; Zhou, Chu-ren; Hao, Tao-fang; Pan, Tao; Wu, Chun; Li, Zheng-ran; Zhu, Duo; Wang, Hao-fan; Huang, Ming-sheng published an article.Synthetic Route of 443-72-1 The title of the article was DNA N6-methyladenine involvement and regulation of hepatocellular carcinoma development. And the article contained the following:
DNA N6-methyladenine (6 mA) is a new type of DNA methylation identified in various eukaryotic cells. However, its alteration and genomic distribution features in hepatocellular carcinoma (HCC) remain elusive. In this study, we found that N6AMT1 overexpression increased HCC cell viability, suppressed apoptosis, and enhanced migration and invasion, whereas ALKBH1 overexpression induced the opposite effects. Further, 23,779 gain-of-6 mA regions and 11,240 loss-of-6 mA regions were differentially identified in HCC tissues. The differential gain and loss of 6 mA regions were considerably enriched in intergenic regions. Moreover, 7% of the differential 6 mA modifications were associated with tumors, with 60 associated with oncogenes and 57 with tumor suppressor genes (TSGs), and 17 were common to oncogenes and TSGs. The candidate genes affected by 6 mA were filtered by gene ontol. (GO) and RNA-seq. Using quant. polymerase chain reaction (qPCR), BCL2 and PARTICL were found to be correlated with DNA 6 mA in certain HCC processes. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Synthetic Route of 443-72-1
The Article related to dna n6methyladenine regulation hepatocellular carcinoma development, alkbh1, genomic distribution, hepatocellular carcinoma, n6-methyladenine, n6amt1, Biochemical Genetics: Other and other aspects.Synthetic Route of 443-72-1
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Imidazole | C3H4N2 – PubChem