Grunberg, E.; Titsworth, E. published an article in 1965, the title of the article was Toxicity and antitrichomonad activity of 2-nitroimidazole and 2-nitrobenzimidazole derivatives.Formula: C7H5N3O2 And the article contains the following content:
2-Nitroimidazole, 2-nitrobenzimidazole, and their alkyl, alkoxy, and chloro derivatives were generally moderately to highly toxic in mice. Only 1,4,5-trimethyl-2-nitroimidazole and 5,6-dimethyl-2-nitrobenzimidazole were relatively atoxic. 2-Nitroimidazole and certain of its Me derivatives were active orally against Trichomonas foetus infection in mice as well as subcutaneously against local T. vaginalis infection in mice. The 1-allyl derivative was inactive orally against T. foetus, but did show activity by both the subcutaneous and oral routes against T. vaginalis. 2-Nitrobenzimidazole and its alkyl, alkoxy, and chloro derivatives were without oral activity against either T. vaginalis or T. foetus. The majority of the 2-nitrobenzimidazole derivatives tested showed slight to moderate activity subcutaneously against local T. vaginalis infection of mice. The experimental process involved the reaction of 2-Nitro-1H-benzo[d]imidazole(cas: 5709-67-1).Formula: C7H5N3O2
2-Nitro-1H-benzo[d]imidazole(cas:5709-67-1) belongs to imidazoles. It is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Formula: C7H5N3O2
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem