On January 24, 1981, Barbin, Alain; Bartsch, Helmut; Leconte, Philippe; Radman, Miroslav published an article.Application of 55662-66-3 The title of the article was Studies on the miscoding properties of 1,N6-ethenoadenine and 3,N4-ethenocytosine, DNA reaction products of vinyl chloride metabolites, during in vitro DNA synthesis. And the article contained the following:
1-N6-Ethenoadenine (EA)(I) [13875-63-3] and 3,N4-ethenocytosine (EC) [55662-66-3] are formed when electrophilic vinyl chloride (VC) metabolites, chloroethylene oxide (CEO) [7763-77-1] or chloroacetaldehyde (CAA) [107-20-0] react with adenine [73-24-5] and cytosine [71-30-7] residues in DNA. They were assayed for their miscoding properties in an in vitro system using Escherichia coli DNA polymerase I and synthetic templates prepared by reaction of poly(dA) and poly(dC) with increasing concentrations of CEO or CAA. Following the introduction of etheno groups, an increasing inhibition of DNA synthesis was observed DGMP was misincorporated on CAA- or CEO-teated poly(dA) templates and dTMP was misincorporated on CAA- or CEO-treated poly(dC) templates, suggesting that EA and EC may miscode. The error rates augmented with the extent of reaction of CEO or CAA with the templates. The potentially miscoding properties of EA and EC may explain why metabolically-activated VC and its reactive metabolites specifically induce base-pair substitution mutations in Salmonella typhimurium. Promutagenic lesions may represent one of the initial steps in VC- or CEO-induced carcinogenesis. The experimental process involved the reaction of Imidazo[1,2-c]pyrimidin-5(6H)-one(cas: 55662-66-3).Application of 55662-66-3
The Article related to vinyl chloride dna reaction product, ethenoadenine vinyl chloride dna, ethenocytosine vinyl chloride dna, carcinogen vinyl chloride dna, Toxicology: Carcinogens and other aspects.Application of 55662-66-3
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem