On March 31, 1986, Vance, William A.; Okamoto, Howard S.; Wang, Yi Y. published an article.Recommanded Product: 5709-67-1 The title of the article was Structure-activity relationships of nitro and methyl-nitro derivatives of indoline, indole, indazole and benzimidazole in Salmonella typhimurium. And the article contained the following:
The mutagenic activities of I (R = H or Me) and II (R = H or Me; X = Y = CH or N) were investigated in Salmonella TA 98 and 100. The presence of a NO2 group at C4 or C7 resulted in only weakly or nonmutagenic compounds, while a NO2 group at C2, C5 or C6 usually resulted in measurable mutagenic activity in the non-N-methylated compounds Methylation of a ring N usually reduced the mutagenic activity of these nitroheterocyclics except 2-nitrobenzimidazole [5709-67-1], which resulted in a better than 300-fold increase in mutagenic activity. A proposed mechanism for the increased mutagenic activity obtained by methylation of imidazole N may provide insights into the reasons for the potent mutagenicities observed for several similarly methylated cooked-food mutagens. The experimental process involved the reaction of 2-Nitro-1H-benzo[d]imidazole(cas: 5709-67-1).Recommanded Product: 5709-67-1
The Article related to mutagenicity nitro nitrogen heterocycle, Toxicology: Carcinogens, Mutagens, and Teratogens and other aspects.Recommanded Product: 5709-67-1
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem