On March 31, 2021, Zhang, Xing; Blumenthal, Robert M.; Cheng, Xiaodong published an article.Recommanded Product: N-Methyl-7H-purin-6-amine The title of the article was A Role for N6-Methyladenine in DNA Damage Repair. And the article contained the following:
The leading cause of mutation due to oxidative damage is 8-oxo-2′-deoxyguanosine (8-oxoG) mispairing with adenine (Ade), which can occur in two ways. First, guanine of a G:C DNA base pair can be oxidized. If not repaired in time, DNA polymerases can mispair Ade with 8-oxoG in the template. This 8-oxoG:A can be repaired by enzymes that remove Ade opposite to template 8-oxoG, or 8-oxoG opposite to Cyt. Second, free 8-oxo-dGTP can be misincorporated by DNA polymerases into DNA opposite template Ade. However, there is no known repair activity that removes 8-oxoG opposite to template Ade. We suggest that a major role of N6-methyladenine in mammalian DNA is minimizing incorporation of 8-oxoG opposite to Ade by DNA polymerases following adduct formation. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Recommanded Product: N-Methyl-7H-purin-6-amine
The Article related to methyladenine dna damage repair, 8-oxoguanine, dna adenine methylation, mettl3-mettl14, ythdc1, single-stranded dna, General Biochemistry: Nucleic Acids and Their Constituents and other aspects.Recommanded Product: N-Methyl-7H-purin-6-amine
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem