On June 30, 2021, Zhang, Pengyue; Gao, Jingjing; Li, Xinxu; Feng, Yilong; Shi, Manli; Shi, Yining; Zhang, Wenli published an article.Electric Literature of 443-72-1 The title of the article was Interplay of DNA and RNA N6-methyladenine with R-loops in regulating gene transcription in Arabidopsis. And the article contained the following:
R-loops and covalent modifications of N6-methyladenine on DNA (D-6 mA) or RNA (R-m6A) have been documented to function in various cellular processes in eukaryotes. However, the relationships between R-loops and both covalent modifications are still elusive in plants. Here, we integrated existing ssDRIP-seq with D-6 mA and R-m6A data from Arabidopsis thaliana. We found that the presence of either of both modifications facilitates R-loop formation and transcription of overlapping genes. Interestingly, our study suggests that the presence of R-m6A is key to affect R-loop intensity and pos. regulate gene transcription. Moreover, the presence of D-6 mA plays an additive role to facilitate the effect of R-m6A on R-loop intensity, however, D-6 mA may neg. regulate gene transcription when coexisted with R-m6A. Our analyses indicate that D-6 mA, R-m6A, or histone marks may act individually and cooperatively with R-loops in regulating gene transcription. Our study is the first to link R-loops with D-6 mA and R-m6A in plants, thereby providing new insights into interactions between R-loops with D-6 mA, R-m6A, and histone marks for regulating gene transcription. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Electric Literature of 443-72-1
The Article related to dna rna n6 methyladenine gene transcription arabidopsis, dna-6 ma, gene transcription, histone marks, plants, r-loops, rna-m6a, Biochemical Genetics: Gene Structure and Organization and other aspects.Electric Literature of 443-72-1
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Imidazole | C3H4N2 – PubChem