Yang, Xiao; Ye, Xiucai; Li, Xuehong; Wei, Lesong published an article in 2021, the title of the article was iDNA-MT: identification DNA modification sites in multiple species by using multi-task learning based a neural network tool.Quality Control of N-Methyl-7H-purin-6-amine And the article contains the following content:
DNA N4-methylcytosine (4mC) and N6-methyladenine (6mA) are two important DNA modifications and play crucial roles in a variety of biol. processes. Accurate identification of the modifications is essential to better understand their biol. functions and mechanisms. However, existing methods to identify 4mA or 6mC sites are all single tasks, which demonstrates that they can identify only a certain modification in one species. Therefore, it is desirable to develop a novel computational method to identify the modification sites in multiple species simultaneously. In this study, we proposed a computational method, called iDNA-MT, to identify 4mC sites and 6mA sites in multiple species, resp. The proposed iDNA-MT mainly employed multi-task learning coupled with the bidirectional gated recurrent units (BGRU) to capture the sharing information among different species directly from DNA primary sequences. Exptl. comparative results on two benchmark datasets, containing different species resp., show that either for identifying 4mA or for 6mC site in multiple species, the proposed iDNA-MT outperforms other state-of-the- art single-task methods. The promising results have demonstrated that iDNA-MT has great potential to be a powerful and practically useful tool to accurately identify DNA modifications. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Quality Control of N-Methyl-7H-purin-6-amine
The Article related to dna modification site multi task learning neural network tool, dna modification, deep learning, feature representation, multi-task learning, neural network, Biochemical Methods: Other (Not Covered At Other Subsections) and other aspects.Quality Control of N-Methyl-7H-purin-6-amine
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem