On December 31, 2020, Wang, Hao-Tian; Xiao, Fu-Hui; Li, Gong-Hua; Kong, Qing-Peng published an article.Reference of N-Methyl-7H-purin-6-amine The title of the article was Identification of DNA N6-methyladenine sites by integration of sequence features. And the article contained the following:
Abstract: Background: An increasing number of nucleic acid modifications have been profiled with the development of sequencing technologies. DNA N6-methyladenine (6mA), which is a prevalent epigenetic modification, plays important roles in a series of biol. processes. So far, identification of DNA 6mA relies primarily on time-consuming and expensive exptl. approaches. However, in silico methods can be implemented to conduct preliminary screening to save exptl. resources and time, especially given the rapid accumulation of sequencing data. Results: In this study, we constructed a 6mA predictor, p6mA, from a series of sequence-based features, including physicochem. properties, position-specific triple-nucleotide propensity (PSTNP), and electron-ion interaction pseudopotential (EIIP). We performed maximum relevance maximum distance (MRMD) anal. to select key features and used the Extreme Gradient Boosting (XGBoost) algorithm to build our predictor. Results demonstrated that p6mA outperformed other existing predictors using different datasets. Conclusions: p6mA can predict the methylation status of DNA adenines, using only sequence files. It may be used as a tool to help the study of 6mA distribution pattern. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Reference of N-Methyl-7H-purin-6-amine
The Article related to dna nitrogen methyladenine algorimthm, dna n6-methyladenine, machine learning, xgboost, Biochemical Methods: Other (Not Covered At Other Subsections) and other aspects.Reference of N-Methyl-7H-purin-6-amine
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem