On November 3, 1977, Schweisguth, Bernard published a patent.Safety of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one The title of the patent was (Morpholinylmethyl)benzimidazolinones. And the patent contained the following:
Antidepressant morpholine derivatives I (R = Me, Me2CH, Ph, PhCH2; R1 = H, 6-Cl, 5-MeO; R2 = H, PhCH2; X = N, CH) (12 compounds) were prepared Thus, 1-methyl-2,3-dihydro-2-benzimidazolone reacted with NaH and 2-(chloromethyl)-4-benzylmorpholine to give I (R = Me, R1 = H, R2 = PhCH2), which was hydrogenated to I (R2 = H). I are useful as antidepressants at 50-150 mg/day for humans. The experimental process involved the reaction of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one(cas: 41010-50-8).Safety of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one
The Article related to morpholinylmethylbenzimidazolone, antidepressant morpholinylmethylbenzimidazolone, benzimidazolone morpholinylmethyl, Heterocyclic Compounds (More Than One Hetero Atom): Oxazines and other aspects.Safety of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem