On December 31, 2022, Rodriguez, Fernando; Yushenova, Irina A.; DiCorpo, Daniel; Arkhipova, Irina R. published an article.SDS of cas: 443-72-1 The title of the article was Bacterial N4-methylcytosine as an epigenetic mark in eukaryotic DNA. And the article contained the following:
DNA modifications are used to regulate gene expression and defend against invading genetic elements. In eukaryotes, modifications predominantly involve C5-methylcytosine (5mC) and occasionally N6-methyladenine (6mA), while bacteria frequently use N4-methylcytosine (4mC) in addition to 5mC and 6mA. Here we report that 4mC can serve as an epigenetic mark in eukaryotes. Bdelloid rotifers, tiny freshwater invertebrates with transposon-poor genomes rich in foreign genes, lack canonical eukaryotic C5-methyltransferases for 5mC addition, but encode an amino-methyltransferase, N4CMT, captured from bacteria >60 Mya. N4CMT deposits 4mC at active transposons and certain tandem repeats, and fusion to a chromodomain shapes its “histone-read-DNA-write” architecture recognizing silent chromatin marks. Furthermore, amplification of SETDB1 H3K9me3 histone methyltransferases yields variants preferentially binding 4mC-DNA, suggesting “DNA-read-histone-write” partnership to maintain chromatin-based silencing. Our results show how non-native DNA Me groups can reshape epigenetic systems to silence transposons and demonstrate the potential of horizontal gene transfer to drive regulatory innovation in eukaryotes. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).SDS of cas: 443-72-1
The Article related to bdelloid epigenetics n4 methylcytosine dna, General Biochemistry: Proteins and Their Constituents and other aspects.SDS of cas: 443-72-1
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem