Mohan, T. S. S. Jagan; Varma, Datla Peda; Bhavyasri, Khagga; Prasad, Kancherla; Mukkanti, Khagga; Jogia, Hitesh A. published an article in 2017, the title of the article was HPLC method for determining esomeprazole and its related substances in pharmaceutical formulations.Application of 73590-85-9 And the article contains the following content:
A green, novel, selective, rapid, precise, accurate and simple isocratic reverse phase stability indicating RP-HPLC method has been developed and validated as per ICH guidelines for estimation of esomeprazole and its impurities in pharmaceutical formulations. Inertsil ODS (150 × 4.6 mm, 5 μ) stationary phase by using mobile phase 0.05 % glacial acetic acid and isopropanol in the ratio of 85:15 volume/volume at flow rate of 1.0 mL/min and column temperature of 50 °C. Esomeprazole was detected at 280 nm. The proposed method was validated as per ICH guidelines for precision, accuracy, specificity, robustness and sensitivity. The proposed method proves its stability by resolving esomeprazole peak from its degradation products in forced degradation study. The proposed method is not only eco-friendly but faster than the official method in EP 8.0 by meeting resolution criteria as per the monograph. The proposed method was capable to determine assay of esomeprazole in the presence of its related substances within the same run. The proposed method can be used for routine anal. in quality control laboratories for its pharmaceutical formulations. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Application of 73590-85-9
The Article related to esomeprazole impurity tablet formulation hplc, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Application of 73590-85-9
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem