On October 14, 2021, Liu, Tao; Zhou, Shubao; Wang, Shaomeng; Zhang, Meng; Xu, Fuming; Zhou, Haibin; Aguilar, Angelo; Huang, Liyue published a patent.Safety of 4-Bromo-1H-benzo[d]imidazol-2(3H)-one The title of the patent was Preparation of piperidine derivatives as menin inhibitors and methods of use for treating cancer. And the patent contained the following:
The present disclosure provides compounds represented by Formula (I): or a pharmaceutically acceptable salt thereof, wherein Ra, Rb, Rc, Rd, L1, R2 B, Q and E are as defined as set forth in the specification. The present disclosure also provides compounds of Formula (I) for use to treat cancer or any other disease, condition, or disorder that is responsive to inhibition of menin. :. The disclosure provides compounds represented by formula I, or a pharmaceutically acceptable salt thereof. The disclosure also provides compounds of formula I for use to treat cancer or any other disease, condition, or disorder that is responsive to inhibition of menin. Compounds of formula I wherein n is 0, 1 and 2; each Ra and each Rb are independently H and C1-4 alkyl; Rc is H and halo; each R4 is independently halo; Q is NHCO2R; R is C1-4 alkyl, C1-4 haloalkyl and CD3; B is imidazolylmethyl, pyrazolylmethyl, CH2OH, etc.; E is (un)substituted sulfonylphenyl, (un)substituted Ph, (un)substituted pyrimidinyl, etc.; L1 is CH2; and pharmaceutically acceptable salt thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their menin inhibitory activity. From the assay, it was determined that compound II exhibited IC50 values of less than 50 nM. The experimental process involved the reaction of 4-Bromo-1H-benzo[d]imidazol-2(3H)-one(cas: 40644-16-4).Safety of 4-Bromo-1H-benzo[d]imidazol-2(3H)-one
The Article related to piperidine preparation menin inhibitor treatment cancer, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Safety of 4-Bromo-1H-benzo[d]imidazol-2(3H)-one
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem