Liu, Hong; Li, Yuan; Chen, Yan; Zhao, Haipeng published an article in 2015, the title of the article was Main component self-comparison with calibration factor method for determination of related substances in Omeprazole Enteric Capsules.Product Details of 73590-85-9 And the article contains the following content:
Objective: To establish the main component self-comparison with calibration factor method to determine the contents of related substances in Omeprazole Enteric Capsules. Methods: An Agilent HC-C8 column (4.6 mm × 250 mm, 5 μm) was adopted with the mobile phase composed of 0.01 mol·L-1 disodium hydrogen phosphate (adjusted to pH 7.6 with phosphoric acid) and acetonitrile in the ratio of 75:25 pumped at a flow rate of 1.0 mL·min-1. The detection was carried out at 280 nm and a column temperature of 35°C. The injection volume was 20 μL. The slope of linear equation was used to determine the correction factor between impurities A, B, C, D and omeprazole. The relative retention time was used to determine the position of impurities. Results: The relative retention time between impurities A, B, C, D and omeprazole was 0.27, 0.31, 0.41 and 0.79, resp. The correction factor of impurities A, B, C, D was 1.20, 0.58, 0.57 and 1.04, resp. The content of impurity D was 0.022% in three batches of samples. Other impurities were not detected. Conclusion: The method is simple, efficient and accurate for analyzing the related substances in Omeprazole Enteric Capsules. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Product Details of 73590-85-9
The Article related to omeprazole enteric capsule related substance, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Product Details of 73590-85-9
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem