On November 21, 2019, Yang, Wenjin; Chang, Kai-Wei; Liu, Suying; Tsai, Cheng-Han published a patent.Reference of 5-Bromo-1H-imidazole-4-carbaldehyde The title of the patent was Preparation of imidazolidines as matrix metalloproteinase (MMP) inhibitors useful in treatment of diseases. And the patent contained the following:
The invention relates to preparation of hydantoin-based compounds (I) useful as inhibitors of matrix metalloproteinases (MMPs), particularly macrophage elastase (MMP-12) are described. Compounds I wherein ring B is (un)substituted aryl or heteroaryl; ring C is aryl or heteroaryl; ring D is aryl or heteroaryl; each X, Y, and Z each independently is O, CH2, NH, etc.; R1 is H or alkyl; R2 is H, halo, OH, etc.; R3 is H, halo, alkyl, etc.; R4 is H or alkyl; R5 is H; m is 1-4; n is 1-5, are claimed. The example compound II was prepared by a synthetic procedure from the intermediate compound(also prepared) (procedure given). Compounds I were evaluated for their biol. activities including selective MMP inhibiting activity (data given). Compounds I and related compositions are selective inhibitors of MMP-12 and can be used in treatment of diseases mediated by MMP-12, such as asthma, chronic obstructive pulmonary disease (COPD), emphysema, acute lung injury, idiopathic pulmonary fibrosis (IPF), sarcoidosis, systemic sclerosis, liver fibrosis, nonalcoholic steatohepatitis (NASH), arthritis, cancer, heart disease, inflammatory bowel disease (IBD), acute kidney injury (AKI), chronic kidney disease (CKD), Alport syndrome, and nephritis. The experimental process involved the reaction of 5-Bromo-1H-imidazole-4-carbaldehyde(cas: 50743-01-6).Reference of 5-Bromo-1H-imidazole-4-carbaldehyde
The Article related to imidazolidine preparation selective mmp inhibitor disease treatment, hydantoin preparation selective macrophage elastase mmp12 inhibitor disease treatment, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Reference of 5-Bromo-1H-imidazole-4-carbaldehyde
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem