On January 20, 2022, Venkatraman, Shankar; Katz, Jason; Roush, William R.; Seidel, Hans Martin published a patent.Category: imidazoles-derivatives The title of the patent was Preparation of indoles, imidazopyridines, pyrazolopyrimidines and related heterocycles useful alone or in compositions in treatment of diseases associated with STING activity. And the patent contained the following:
The invention relates to preparation of indoles, imidazopyridines, pyrazolopyrimidines and related heterocycles(I) or a pharmaceutically acceptable salt, hydrate, cocrystal, or drug combination that inhibit (e.g., antagonize) Stimulator of Interferon Genes (STING). Compounds I wherein X1 and X2 each independently is O, S, N, etc.; Z and Y1-Y3 each independently is heteroaryl; ring B is bicyclic or polycyclic C5-15 cycloalkyl or C5-15 cycloalkenyl, etc.; etc., are claimed. The example compound II was prepared via 4-steps synthesis using 5-bromo-1H-indole as starting material (procedure given). Compounds I were evaluated for their biol. activity (data given). Compounds I are useful, e.g., for treating a diseases in which increased (e.g., excessive) STING activation (e.g., STING signaling) contributes to the pathol. and/or symptoms and/or progression of the disease (e.g., cancer) in a subject (e.g., a human). The experimental process involved the reaction of 6-(Trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-2-carboxylic acid(cas: 1774893-22-9).Category: imidazoles-derivatives
The Article related to pyrazolopyrimidine preparation sting activation inhibitor cancer disease treatment, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Category: imidazoles-derivatives
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem