On January 15, 2013, Si, Yuhui; Sun, Gangchun; Li, Zhicheng; Li, Yaping published an article.HPLC of Formula: 73590-85-9 The title of the article was Synthesis and resolution of omeprazole. And the article contained the following:
Omeprazole was synthesized and resolved by chiral resolution agent to obtain the S-isomer (Esomeprazole). The resolving conditions were as follows: S-(-)-1, 1′-Binaphthyl-2, 2′-diol, racemic omeprazole and alkali (molar ratio 1:1.6:1.8) reacted in ethanol and water (3.7:1 in v:v) at room temperature for 12 h. The magnesium salt of Esomeprazole was obtained in a high yield (89%) and excellent enantioselectivity (97.95% ee). The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).HPLC of Formula: 73590-85-9
The Article related to esomeprazole omeprazole synthesis chiral resolution, Pharmacology: Other (All Agents and Effects Not Otherwise Assignable) and other aspects.HPLC of Formula: 73590-85-9
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem