On August 31, 2015, Liu, Xiao-ping; Xu, Hui-lan; Sun, Rui; Li, Xue; Hu, Bao-hua; Hu, Chun published an article.Synthetic Route of 73590-85-9 The title of the article was Synthesis and characterization of two impurities in esomeprazole, an antiulcerative drug. And the article contained the following:
Impurity control is a key factor for drug quality. Study for impurities is helpful to optimize the production process and improve the quality of drugs. Synthesis and characterization of two of impurities in esomeprazole, which used for treatment of acid-related diseases was described in this paper. The two impurities are known as 2-[(3,5-dimethyl-4-methoxy-2-pyridinyl)methylsulfinyl]-1H-benzimidazole (impurity 1) and (R)-5-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1H-benzimidazole (esomeprazole impurity F), whose structures are characterized with MS, IR, 1H-NMR and elemental analyses, and the purities of the two impurities are above 99% by HPLC anal. The two target compounds can be used as the reference substance of the impurities of esomeprazole. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Synthetic Route of 73590-85-9
The Article related to antiulcerative drug esomeprazole impurity acid disease, Pharmacology: Other (All Agents and Effects Not Otherwise Assignable) and other aspects.Synthetic Route of 73590-85-9
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem