Li, Zutan; Jiang, Hangjin; Kong, Lingpeng; Chen, Yuanyuan; Lang, Kun; Fan, Xiaodan; Zhang, Liangyun; Cong, Pian published an article in 2021, the title of the article was Deep6mA: A deep learning framework for exploring similar patterns in DNA N6-methyladenine sites across different species.Recommanded Product: 443-72-1 And the article contains the following content:
N6-methyladenine (6mA) is an important DNA modification form associated with a wide range of biol. processes. Identifying accurately 6mA sites on a genomic scale is crucial for under-standing of 6mA’s biol. functions. However, the existing exptl. techniques for detecting 6mA sites are cost-ineffective, which implies the great need of developing new computational methods for this problem. In this paper, we developed, without requiring any prior knowledge of 6mA and manually crafted sequence features, a deep learning framework named Deep6mA to identify DNA 6mA sites, and its performance is superior to other DNA 6mA prediction tools. Specifically, the 5-fold cross-validation on a benchmark dataset of rice gives the sensitivity and specificity of Deep6mA as 92.96% and 95.06%, resp., and the overall prediction accuracy is 94%. Importantly, we find that the sequences with 6mA sites share similar patterns across different species. The model trained with rice data predicts well the 6mA sites of other three species: Arabidopsis thaliana, Fragaria vesca and Rosa chinensis with a prediction accuracy over 90%. In addition, we find that (1) 6mA tends to occur at GAGG motifs, which means the sequence near the 6mA site may be conservative; (2) 6mA is enriched in the TATA box of the promoter, which may be the main source of its regulating downstream gene expression. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Recommanded Product: 443-72-1
The Article related to arabidopsis fragaria rosa n6 methyladenine dna, Plant Biochemistry: Photosynthesis (Algae, Bacteria, and Green Plants) and other aspects.Recommanded Product: 443-72-1
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem