On September 28, 1992, Li, M. J.; Li, S. Z.; Zhuang, X. L.; Chen, A.; Zhang, H. Q.; Pang, X. C.; Hu, B. published an article.Application of 5709-67-1 The title of the article was Synthesis and radiosensitizing activity of benzimidazoles. And the article contained the following:
Reaction of 2-nitrobenzimidazole with Et chloroformate yielded Et (2-nitrobenzimidazol-1-yl)formate or Et (2-hydroxybenzimidazol-1-yl)formate, depending upon the solvents used. Reaction of 2-nitrobenzimidazole with 1,2-epoxy-3-chloropropane gave a cyclized compound I. In an attempt to increase hydrophilicity, 1-substituted 2-(3′-pyridyl)-5-nitrobenzimidazoles were prepared by reaction of 2-(3′-pyridyl)-5(6)-nitrobenzimidazole with alkyl epoxides or Et chloroacetate. Some of the compounds synthesized were tested for radiosensitizing activity in Ehrlich ascites carcinoma-bearing mice. Preliminary results showed that some compounds have radiosensitizing activity. The radiosensitizing enhancement ratio (SER) of compounds I and II (R = H, Me) were 1.50, 1.52 and 1.65 resp. The experimental process involved the reaction of 2-Nitro-1H-benzo[d]imidazole(cas: 5709-67-1).Application of 5709-67-1
The Article related to benzimidazole preparation radiosensitizer, nitrobenzimidazole preparation radiosensitizer, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Application of 5709-67-1
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem