On September 3, 2009, Levin, Jeremy Ian; Hopper, Darrin William; Torres, Nancy; Dutia, Minu Dhanjish; Berger, Dan Maarten; Wang, Xiaolun; Di Grandi, Martin Joseph; Zhang, Chunchun; Dunnick, Alejandro Lee published a patent.Synthetic Route of 40644-16-4 The title of the patent was Preparation of bridged, bicyclic heterocyclic or spiro bicyclic heterocyclic derivatives of pyrazolo[1,5-a]pyrimidines as Raf kinase inhibitors.. And the patent contained the following:
Title compounds [I; R1 = (substituted) 5-7 membered heterocyclyl, heteroaryl; R2 = (substituted) (bicyclic) aryl, heteroaryl; R3-R5 = H, cyano, (substituted) alkyl, cycloalkyl aryl, heterocyclyl, heteroaryl, etc.], were prepared Thus, title compound 3-[7-[6-[(1-azabicyclo[2.2.2]oct-4-ylmethyl)amino]pyridin-3-yl]-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-3-yl]phenol [multistep preparation from 5-acetyl-2-bromopyridine, DMF di-Me acetal, 3-methoxyphenylacetonitrile, Me isonicotinate, and 1-(1-azabicyclo[2.2.2]oct-4-yl)methylamine given] inhibited B-Raf kinase with IC50 = 0.002 μM. The experimental process involved the reaction of 4-Bromo-1H-benzo[d]imidazol-2(3H)-one(cas: 40644-16-4).Synthetic Route of 40644-16-4
The Article related to pyrazolopyrimidine preparation raf kinase inhibitor, cancer inflammation treatment azabicyclooctylmethylaminopyridinylpyridin4ylpyrazolopyrimidinylphenol preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Synthetic Route of 40644-16-4
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem