On January 31, 2007, Buhl, Rikke; Ersboell, Annette K.; Larsen, Nanna H.; Eriksen, Lis; Koch, Joergen published an article.Application In Synthesis of N-(2-Bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-amine hydrochloride The title of the article was The effects of detomidine, romifidine or acepromazine on echocardiographic measurements and cardiac function in normal horses. And the article contained the following:
To evaluate by echo- and electrocardiog. the cardiac effects of sedation with detomidine hydrochloride, romifidine hydrochloride or acepromazine maleate in horses. An exptl. study using a crossover design without randomization. Animals Eight clin. normal Standardbred trotters. Echocardiog. examinations (two-dimensional, guided M-mode and color Doppler) were recorded on five different days. Heart rate (HR) and standard limb lead electrocardiograms were also obtained. Subsequently, horses were sedated with detomidine (0.01 mg kg-1), romifidine (0.04 mg kg-1) or acepromazine (0.1 mg kg-1) administered i.v. and all examinations repeated. Heart rate before treatment with the three drugs did not differ significantly (p = 0.98). Both detomidine and romifidine induced a significant decrease (p < 0.001) in HR during the first 25 min after sedation; while acepromazine had a varying effect on HR. For detomidine, there was a significant increase in LVIDd (left ventricular internal diameter in diastole; p = 0.034) and LVIDs (left ventricular internal diameter in systole; p < 0.001). In addition, a significant decrease was found in IVSs (the interventricular septum in systole; p < 0.001), LVFWs (the left ventricular free wall in systole; p = 0.002) and FS% (fractional shortening; p < 0.001). The frequency of pulmonary regurgitation was increased significantly (p < 0.001). Romifidine induced a significant increase in LVIDs (p < 0.001) and a significant decrease in IVSs (p < 0.001) and FS% (p = 0.002). Acepromazine had no significant effect upon any of the measured values. The results indicate that sedation of horses with detomidine and to a lesser extent romifidine at the doses given in this study has a significant effect on heart function, echocardiog. measurements of heart dimensions and the occurrence of valvular regurgitation. Although the clin. significance of these results may be minimal, the potential effects of sedative drugs should be taken into account when echocardiog. variables are interpreted in clin. cases. The experimental process involved the reaction of N-(2-Bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-amine hydrochloride(cas: 65896-14-2).Application In Synthesis of N-(2-Bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-amine hydrochloride
The Article related to horse heart rate electrocardiog echocardiog domosedan sedivet plegicil sedative, Pharmacology: Effects Of Cardiovascular, Hematologic, and Renal Drugs and other aspects.Application In Synthesis of N-(2-Bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-amine hydrochloride
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