On December 13, 2019, Aspnes, Gary Erik; Bagley, Scott W.; Curto, John M.; Edmonds, David James; Flanagan, Mark E.; Futatsugi, Kentaro; Griffith, David A.; Huard, Kim; Lian, Yajing; Limberakis, Chris; Londregan, Allyn T.; Mathiowetz, Alan M.; Piotrowski, David W.; Riggeri, Roger B. published a patent.Category: imidazoles-derivatives The title of the patent was Preparation of 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, and 7-aza-benzimidazoles as GLP-1R agonists for the treatment of diseases. And the patent contained the following:
Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, and 7-aza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof. The example compound (I) was prepared by multistep synthesis (procedure given). The compounds of the invention were evaluated for their biol. activity (data given). The compounds of the invention can be used in treatment of diseases, such as NASH, diabetes, obesity and like. The experimental process involved the reaction of (1-Ethyl-1H-imidazol-5-yl)methanamine dihydrochloride(cas: 1255717-13-5).Category: imidazoles-derivatives
The Article related to benzimidazole carboxylic acid salt preparation glp1r agonist disease treatment, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Category: imidazoles-derivatives
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem