On November 26, 2020, Aspnes, Gary E.; Bagley, Scott W.; Curto, John M.; Dowling, Matthew; Edmonds, David James; Fernando, Dilinie; Flanagan, Mark E.; Futatsugi, Kentaro; Griffith, David Andrew; Huard, Kim; Ingle, Gajendra; Jiao, Wenhua; Lacasse, Shawn M.; Lian, Yajing; Limberakis, Chris; Londregan, Allyn T.; Mathiowetz, Alan M.; Piotrowski, David Walter; Ruggeri, Roger B.; Wiglesworth, Kristin published a patent.Application In Synthesis of (1-Ethyl-1H-imidazol-5-yl)methanamine dihydrochloride The title of the patent was Combinations comprising benzodioxol as GLP-1R agonists for use in the treatment of NASH/NAFLD and related diseases and their preparation. And the patent contained the following:
The invention provides a new combination comprising (1) a GLP-1R agonist and (2) an ACC inhibitor or a DGAT2 inhibitor, or a KHK inhibitor or FXR agonist. The invention further provides new methods for treating diseases and disorders, for example, fatty liver, nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, nonalcoholic steatohepatitis with liver fibrosis, nonalcoholic steatohepatitis with cirrhosis, and nonalcoholic steatohepatitis with cirrhosis and with hepatocellular carcinoma or with a metabolic-related disease, obesity, and type 2 diabetes, for example, using the new combination described herein. Example compound I•TFA was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their GLP-1R agonistic activity (some data given). The experimental process involved the reaction of (1-Ethyl-1H-imidazol-5-yl)methanamine dihydrochloride(cas: 1255717-13-5).Application In Synthesis of (1-Ethyl-1H-imidazol-5-yl)methanamine dihydrochloride
The Article related to benzodioxole preparation glp 1r agonist treatment nash nafld, Heterocyclic Compounds (More Than One Hetero Atom): Dioxoles, Oxathioles, Dithioles and other aspects.Application In Synthesis of (1-Ethyl-1H-imidazol-5-yl)methanamine dihydrochloride
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem