On May 31, 2009, Schauvliege, Stijn; Van den Eede, Annelies; Duchateau, Luc; Pille, Frederik; Vlaminck, Lieven; Gasthuys, Frank published an article.Recommanded Product: 65896-14-2 The title of the article was Comparison between lithium dilution and pulse contour analysis techniques for cardiac output measurement in isoflurane anaesthetized ponies: influence of different inotropic drugs. And the article contained the following:
Objective: To compare cardiac output (Q虈t) measurements using lithium dilution (LiDCO) and pulse contour anal. (PulseCO) techniques in isoflurane-anesthetized ponies before and during the administration of different inotropic/vasoactive drugs. Study design: Prospective randomized exptl. cross-over trial. Animals: Six ponies aged 5.0 卤 1.6 (4-6.5) years and weighing 286 卤 53 (212-368) kg. Methods: After sedation (romifidine) and induction (midazolam + ketamine), anesthesia was maintained with isoflurane in oxygen. After 90 min (= T0), one of four treatments was administered: saline 0.1 mL kg-1 (S), enoximone 0.5 mg kg-1 IV (E), enoximone followed by dobutamine (0.5 渭g kg-1 minute-1 for 120 min) (ED) or enoximone followed by a calcium chloride infusion (0.5 mg kg-1 minute-1 for 10 min) (EC). Data were recorded for 120 min after T0. The PulseCO (recorded from carotid artery) was calibrated before T0, no further recalibrations were performed. Q虈t was determined with LiDCO (Q虈tLiDCO) and PulseCO (Q虈tPulseCO) simultaneously at T5, T10, T20, T40, T60, T80, T100 and T120. Systemic vascular resistance (SVRLiDCO and SVRPulseCO) were calculated Results: In the saline group, Q虈tPulseCO was 4.9 卤 12.3% lower than LiDCO (p < 0.01), whereas SVRPulseCO was 6.9 卤 14.4% higher than SVRLiDCO (p < 0.01). These differences increased over time (mean 卤 SEM), Q虈t by 0.06 卤 0.03% minute-1 (p = 0.042) and SVR by 0.08 卤 0.03% minute-1 (p = 0.018). Q虈tPulseCO was higher than Q虈tLiDCO in the EC group (1.8 卤 23.3%), but lower than Q虈tLiDCO in groups E (-11.7 卤 20.4%) and ED (-10.0 卤 25.9%) (significant difference between treatments, p < 0.01). The differences in SVR in groups E (20.4 卤 32.0%) and ED (20.7 卤 35.3%) were significantly higher than in groups S (6.9 卤 14.4%) and EC (3.1 卤 22.2%) (p < 0.01). Conclusions and clin. relevance: Pulse contour anal. values deviated significantly from LiDCO measurements in isoflurane-anesthetized ponies. The experimental process involved the reaction of N-(2-Bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-amine hydrochloride(cas: 65896-14-2).Recommanded Product: 65896-14-2
The Article related to lithium dilution pulse contour analysis cardiac output anesthetic isoflo, inotropic vasoactive enoximone dobutamine mayne, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Recommanded Product: 65896-14-2
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