On July 31, 2009, Rohrbach, Helene; Korpivaara, Toni; Schatzmann, Urs; Spadavecchia, Claudia published an article.HPLC of Formula: 65896-14-2 The title of the article was Comparison of the effects of the alpha-2 agonists detomidine, romifidine and xylazine on nociceptive withdrawal reflex and temporal summation in horses. And the article contained the following:
To evaluate and compare the antinociceptive effects of the three alpha-2 agonists, detomidine, romifidine and xylazine at doses considered equipotent for sedation, using the nociceptive withdrawal reflex (NWR) and temporal summation model in standing horses. Prospective, blinded, randomized crossover study. Ten healthy adult horses weighing 527-645 kg and aged 11-21 years old. Elec. stimulation was applied to the digital nerves to evoke NWR and temporal summation in the left thoracic limb and pelvic limb of each horse. Electromyog. reflex activity was recorded from the common digital extensor and the cranial tibial muscles. After baseline measurements a single bolus dose of detomidine, 0.02 mg/kg-1, romifidine 0.08 mg/kg-1, or xylazine, 1 mg/kg-1, was administered i.v. Determinations of NWR and temporal summation thresholds were repeated at 10, 20, 30, 40, 60, 70, 90, 100, 120, and 130 min after test-drug administration alternating the thoracic limb and the pelvic limb. Depth of sedation was assessed before measurements at each time point. Behavioral reaction was observed and recorded following each stimulation. The administration of detomidine, romifidine and xylazine significantly increased the current intensities necessary to evoke NWR and temporal summation in thoracic limbs and pelvic limbs of all horses compared with baseline. Xylazine increased NWR thresholds over baseline values for 60 min, while detomidine and romifidine increased NWR thresholds over baseline for 100 and 120 min, resp. Temporal summation thresholds were significantly increased for 40.70 and 130 min after xylazine, detomidine and romifidine, resp. Detomidine, romifidine and xylazine, administered i.v. at doses considered equipotent for sedation, significantly increased NWR and temporal summation thresholds, used as a measure of antinociceptive activity. The extent of maximal increase of NWR and temporal summation thresholds was comparable, while the duration of action was drug-specific. The experimental process involved the reaction of N-(2-Bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-amine hydrochloride(cas: 65896-14-2).HPLC of Formula: 65896-14-2
The Article related to alpha 2 agonist domosedan sedivet rompun antinociceptive sedative horse, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.HPLC of Formula: 65896-14-2
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