El-Kammar, M. H.; Gad, S. B.; Korittum, A. S. published an article in 2014, the title of the article was Evaluation of the sedative, analgesic, physiological and haematological effects of intravenous detomidine, detomidine-butorphanol, romifidine and romifidine-butorphanol in Baladi goats.Formula: C9H10BrClFN3 And the article contains the following content:
The present study was aimed to clarify and determine the sedative and analgesic effects of i.v. injection of detomidine, detomidine-butrophanol, romifidine and romifidine-butorphanol in Egyptian Baladi goats and to evaluate the most efficient treatment regimen for induction of sedation and analgesia with the least adverse effects on clinicophysiol. and hematol. parameters. Six baladi goats, three males and three females weighing 25-35 kg were studied in prospective randomized exptl. anesthetic trial. Four i.v. treatments of detomidine, detomidine-butorphanol, romifidine and romifidine-butorphanol were administered to each goat using: 0.04 mg/kg body weight detomidine, 0.04 mg/kg body weight detomidine plus 0.03 mg/kg body weight butorphanol, 0.05 mg/kg body weight romifidine and 0.03 mg/kg body weight romifidine plus 0.05 mg/kg body weight butorphanol. The pulse rate, respiratory rate, rectal temperature, sedation, analgesia, ataxia, Hb, packed cell volume percentage, differential leukocytic count, serum glucose, creatinine, urea, Aspartate aminotransferase and Alanine aminotransferase were evaluated. Marked sedation and complete analgesia was observed after detomidine-butorphanol and romifidine-butorphanol injections. Frequent urination and obvious watery salivation with tympany were observed in all treated goats. A significant reduction in pulse rate was observed in all goats compared to baseline value (p<0.05). Changes in clinicophysiol. and haematol. parameters were transient with no obvious systemic effects. I.v. injection of 0.04 mg/kg body weight detomidine combined with 0.03 mg/kg body weight butorphanol or i.v. injection of 0.05 mg/kg body weight romifidine combined with 0.03 mg/kg body weight butorphanol showed a prolonged marked sedation and complete analgesia in Baladi goats than i.v. injection of detomidine or romifidine alone. The combination of butorphanol with detomidine or romifidine was induced bradycardia, which within acceptable value. The adverse effects on clinicophysiol. and haematol. values were mild, transient and within the physiol. limits. The experimental process involved the reaction of N-(2-Bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-amine hydrochloride(cas: 65896-14-2).Formula: C9H10BrClFN3
The Article related to domosedan torbugesic sedivet sedative analgesic agent goat, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Formula: C9H10BrClFN3
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