On November 30, 2007, Davison, Kathryn E.; Hughes, J. M. Lynne; Gormley, Eamonn; Lesellier, Sandrine; Costello, Eamon; Corner, Leigh A. L. published an article.Electric Literature of 65896-14-2 The title of the article was Evaluation of the anaesthetic effects of combinations of ketamine, medetomidine, romifidine and butorphanol in European badgers (Meles meles). And the article contained the following:
Objective: To evaluate the effects of three anesthetic combinations in adult European badgers (Meles meles). Study design: Prospective, randomized, blinded, exptl. trial. Animals: Sixteen captive adult badgers. Methods: The badgers were each anesthetized by i.m. injection using the three techniques assigned in random order: romifidine 0.18 mg kg-1, ketamine 10 mg kg-1 and butorphanol 0.1 mg kg-1 (RKB); medetomidine 0.1 mg kg-1, ketamine 9 mg kg-1 and butorphanol 0.1 mg kg-1 (MKB); and medetomidine 0.1 mg kg-1 and ketamine 10 mg kg-1 (MK). Initial drug doses were calculated based on a body mass of 10 kg. Addnl. anesthetic requirements, time to drug effect, duration of action and recovery from anesthesia were recorded. Heart rate and rhythm, respiratory rate and rhythm, rectal and s.c. microchip temperature and oxygen saturation were recorded every 5 min. Depth of anesthesia was assessed using: muscle tone; palpebral and pedal reflexes; and tongue relaxation at these time points. Blood samples and a tracheal aspirate were obtained under anesthesia. Atipamezole was administered if the badger had not recovered within 60 min Parametric data were analyzed using ANOVA for repeated measures, and nonparametric data using Friedman’s, and Cochran’s Q tests: p < 0.05 was considered significant. Results: All combinations produced good or excellent muscle relaxation throughout the anesthetic period. RKB had the shortest duration of anesthesia (16.8 min compared with MKB 25.9 min and MK 25.5 min) and antagonism was not required. RKB depressed respiratory rate less than MK and MKB. There was no significant difference between techniques for heart rate and rhythm. Conclusions and clin. relevance: All combinations provided anesthetic conditions suitable for sampling and identification procedures in adult badgers. The RKB protocol provided a significantly shorter period of anesthesia when compared with the combinations containing medetomidine. The experimental process involved the reaction of N-(2-Bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-amine hydrochloride(cas: 65896-14-2).Electric Literature of 65896-14-2
The Article related to anesthetic sedivet narketan torbugesic domitor anesthesia muscle relaxant, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Electric Literature of 65896-14-2
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem